Patents

1.      피부 미백 활성을 갖는 신균주 사카로마이세스 세레비지애 EY2-27 및 이의 용도, 출원, 주발명자

2.      피부미백 활성을 갖는 신균주 워커하모마이세스 아노말루스 EY2-22 및 이의 용도, 출원, 주발명자

3.      지충이 효소 추출물로부터 분리된 다당류 분획물을 유효성분으로 포함하는 기능성 식품, 화장료 조성물 및 이의 제조방법, 출원, 공동발명자

4.      락토바실러스 사케이 검출용 특이 프라이머 세트, 조성물 키트 및 이를 이용한 검출방법, 출원, 공동발명자

5.      식품 및 화장품용 기능성 소재 추출을 위한 산업용 초음파 시스템, 출원, 공동발명자

6.      피부암 억제 활성이 우수한 효모 초음파 추출물의 제조방법 및 상기 방법으로 제조된 효모 초음파 추출물을 함유한 피부암 억제용 조성물, 출원, 공동발명자

7.      감잎 유래 다당 분획물을 유효성분으로 함유하는 인플루엔자 바이러스 감염 질환의 개선, 예방 또는 치료용 조성물, 출원, 공동발명자

8.      보리잎유래 다당 분획물을 유효성분으로 함유하는 인플루엔자 바이러스 감염 질환의 개선, 예방 또는 치료용 조성물, 출원, 공동발명자

9.      피부염증 개선 활성이 우수한 누에고치 유래 파파인 효소 분해물 및 이의 용도, 출원, 공동발명자

10.   혈관 이완능 및 항염 활성이 우수한 누에고치 유래 브로멜라인 효소 분해물 및 이의 용도, 출원, 공동발명자

11.   효모 초음파 추출물을 함유하는 면역기능강화용 식품 조성물 및 효모 초음파 추출물의 제조 방법, 출원, 공동발명자

12.   식품 및 화장품용 기능성 성분 추출을 위한 산업용 초음파 시스템, 출원, 공동발명자

13.   백수오 추출물 또는 백수오 조다당 추출물을 유효성분으로 함유하는 면역기능 향상을 위한 조성물, 등록, 공동발명자

14.   미후등 추출물을 유효성분으로 포함하는 지방간 예방 또는 치료용 조성물, 출원, 공동발명자

15.   효소 분해물을 유효성분으로 함유하는 면역기능 향상을 위한 홍경천복합조성물, 출원, 공동발명자

16.   백수오 조다당 추출물을 유효성분으로 함유하는 대장염의 예방, 개선 및 치료용 조성물, 출원, 공동발명자

17.   진세노사이드 Rg18을 유효성분으로 포함하는 폐암의 개선, 예방 또는 치료용 약제학적 조성물, 등록, 공동발명자

18.   수용성 선인장 열매 분말의 제조방법 및 이에 따라 제조된 수용성 선인장 열매 분말, 등록, 공동발명자

19.   락토바실러스 사케이 K040706을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물, 등록, 공동발명자

20.   가시가 제거된 선인장 분말을 제조하는 방법 및 이에 따라 제조된 선인장 분말, 출원, 공동발명자

21.   식품 및 화장품용 기능성 소재 추출을 위한 산업용 초음파 시스템, 출원, 공동발명자

22.   감잎 유래 다당 분획물을 함유하는 골 관련 질환의 개선, 예방 또는 치료용 조성물, 출원, 공동발명자

23.   보리잎 유래 다당 분획물을 함유하는 골 관련 질환의 개선 예방 또는 치료용 조성물, 출원, 공동발명자

24.   락토바실러스 사케이 2-6-4 균주 및 이의 용도, 등록, 공동발명자

25.   장미 꽃잎 추출물을 포함한 피부 미백용 화장료 조성물, 출원, 주발명자

기술이전

1.      장미꽃잎 추출물을 유효성분으로 포함하는 피부노화 방지용 조성물, 책임자

2.      흑삼추출물의 미백효능 및 작용기전에 대한 실험결과, 책임자

3.      손바닥 선인장분말을 이용한 과립형 제품, 참여연구원

4.      다기능 신균주 락토바실러스 사케이 K040706 alc 이의 배양방법 포함 5건, 참여연구원

5.      Development of ginseng-honey tea using Korean ginseng and Thai honey, 참여연구원

6.      한국식품연구원 개발 증류주 전용 균주 적용 증류주 개발 기술, 참여연구원

7.      혈관 염증질환 예방, 개선효과가 있는 비수리 추출물 및 이의 제조방법, 참여연구원

8.      비가열 추출 참깨박의 기능성 식품 소재화 기술, 참여연구원

9.      가시가 제거된 선인장 분말을 제조하는 방법 및 이에 따라 제조된 선인장 분말, 참여연구원

10.    장미 꽃잎 추출물을 포함한  피부 미백용 화장료 조성물, 책임자

Papers

1.      Eun Ju Shin, Ji Su Lee, Seungpyo Hong, Tae-Gyu Lim^*, Sanguine Byun (2019) Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin. International Journal of Molecular Sciences 20(21)

2.      Su Jin Eom, Nam Hyouck Lee, Min-Cheol Kang, Young Ho Kim, Tae-Gyu Lim^*, Kyung-Mo Song (2020). Silk peptide production from whole silkworm cocoon using ultrasound and enzymatic treatment and its suppression of solar ultraviolet-induced skin inflammation. Ultrasonics Sonochemistry 60

3.      Eun Ju Shin, Seongin Jo, Hyo-kyoung Choi, Sungbin Choi, Sanguine Byun, Tae-Gyu Lim^* (2019). Caffeic Acid Phenethyl Ester Inhibits UV-Induced MMP-1 Expression by Targeting Histone Acetyltransferases in Human Skin. International Journal of Molecular Sciences 20(12)

4.      Ahram Han, Jinhyuk Lee, Myung-hee Lee, Sung-Young Lee, Eun Ju Shin, Young-Ran Song, Kwang Min Lee, Ki Won Lee, Tae-Gyu Lim^* (2019). Sulfuretin, a natural Src family kinases inhibitor for suppressing solar UV-induced skin aging. Journal of Functional Foods 52:442-449

5.      Myung‐hee Lee, Tae Gyu Nam, Inil Lee, Eun Ju Shin, Ah‐ram Han, Pomjoo Lee, Sung‐Young Lee, Tae-Gyu Lim^* (2018). Skin anti‐inflammatory activity of rose petal extract (Rosa gallica) through reduction of MAPK signaling pathway. Food Science & Nutrition 6(8):2560-2567

6.      Tae-Gyu Lim, Yoon-A Kim, Jong-Eun Kim, Sohee Baek, Sung-Young Lee, Charles C. Lee,  Hanyong Chen, Jong Rhan Kim, Jung Yeon Kwon, Ann M. Bode, Chang Yong Lee, Zigang Dong, Deok-Kun Oh, Jun Seong Park, Ki Won Lee. (2018) PKCι is a target of 7,8,4′-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression. Experimental Dermatology 27(5):449-452

7.      Myung-hee Lee, Ah-Ram Han, Mi Jang, Hyo-Kyoung Choi, Sung-Young Lee, Kyung-Tack Kim, Tae-Gyu Lim^* (2018). Antiskin Inflammatory Activity of Black Ginger (Kaempferia parviflora) through Antioxidative Activity. Oxidative Medicine and Cellular Longevity 2018;2018:5967150

8.      Yan Jin, Ji Hye Kim, Hee-Do Hong, Jeonghun Kwon, Eun Jung Lee, Mi Jang, Sung-Young Lee, Ah-Ram Han, Tae Gyu Nam, Seok Kyu Hong, Tae-Lin Huh, Nam Joo Kang, Tae-Gyu Lim^* (2018). Ginsenosides Rg5 and Rk1, the skin-whitening agents in black ginseng. Journal of Functional Foods 45: 67-74

9.      Mi Jang, Chang-Won Cho, Ah-Ram Han, Young Kyoung Rhee, Hee-Do Hong, Kyung-Tack Kim, Sung-Young Lee, Kwang Min Lee, Sung Keun Jung, Tae-Gyu Lim^* (2018). MMP-1 suppressing activity of high-molecular weight fraction isolated from the roots of Cynanchum wilfordii Hemsley. Journal of Functional Foods 40: 329-335

10.   Jong-Eun Kim, Sung-Young Lee, Mi Jang, Hyo-Kyung Choi, Jong Hun Kim, Hanyong Chen, Tae-Gyu Lim^*, Zigang Dong, Ki Won Lee (2017). Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor. International Journal of Molecular Sciences 24;18(10)

11.   Tae-Gyu Lim, Tae Gyu Nam, Bong Han Lee, Sol Lim, Hee Kang, Seok Hyun Eom, Miyoung Yoo, Hae Won Jang, Dae-Ok Kim (2017). Comparison of Anti-Inflammatory Effects of Flavonoid-Rich Common and Tartary Buckwheat Sprout Extracts in Lipopolysaccharide-Stimulated RAW 264.7 and Peritoneal Macrophages. Oxidative Medicine and Cellular Longevity 2017;2017:9658030

12.   Jong-Eun Kim, Young-Gyu Kang, Jun Seong Park, Tae-Gyu Lim^*, Ki Won Lee (2017). Review of Soybean Phytochemicals and Their Bioactive Properties Relevant for Skin Health. Journal of Food and Nutrition Research 5(11):852-858

13.   한아람, 임태규^*(2017). 전통식품의 이너뷰티 소재로서의 적용 가능성 및 전망. 식품산업과 영양 22(2)24-28

14.   Tae-Gyu Lim, Seungmin Han, Jong-Eun Kim, Hee Yang, Deok-Kun Oh, Jung Han Yoon Park, Hee Jung Kim, Young Kyoung Rhee, Ki Won Lee (2017). The ginsenoside derivative 20(S)-protopanaxadiol inhibits solar ultraviolet light-induced matrix metalloproteinase-1 expression. Journal of Cellular Biochemistry 118:3756-3764

15.   Tae-Gyu Lim, Sung-Young Lee, Zhaoheng Duan, Mee-Hyun Lee, Hanyong Chen, Fangfang Liu, Kangdong Liu, Sung Keun Jung, Dong Joon Kim, Ann M. Bode, Ki Won Lee, Zigang Dong (2017). The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4’-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth. Cancer Prevention Research 10(5):308-318

16.   Tae-Gyu Lim, Mi Jang, Sungeun Ahn, Hee-Do Hong, Young Kyoung Rhee, Kyung-Tack Kim, Eunjung Lee, Jeong Hoon Lee, Yun Ji Lee, Chan Sik Jung, Dae Young Lee, Chang-Won Cho (2016). Immune-Enhancing Effects of a High Molecular Weight Fraction of Cynanchum wilfordii Hemsley in Macrophages and Immunosuppressed Mice. Nutrients 27;8(10)

17.   Tae-Gyu Lim, Mi Jang, Chang-Won Cho, Hee-Do Hong, Kyung-Tack Kim, Sung-Young Lee, Sung Keun Jung, Young Kyoung Rhee (2016). White ginseng extract induces immunomodulatory effects via the MKK4-JNK pathway. Food Science and Biotechnology 25(6): 1737-1744

18.   Tae-Gyu Lim, Charles C. Lee, Zigang Dong, Ki Won Lee (2015). Ginsenosides and their metabolites: a review of their pharmacological activities in the skin. Archives of Dermatological Research 307(5): 397-403

19.   Tae-Gyu Lim, Ae Ji Jeon, , Ji Hye Yoon, Nam Joo Kang, Jun-Seong Park, Myeong Hun Yeom, Deok-Kun Oh, Yoongho Lim, and Ki Won Lee (2015). 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginsenoside Rb1, enhances hyaluronic acid production through Src activation in human keratinocytes. International Journal of Molecular Medicine 35: 1388-1394

20.   Tae-Gyu Lim, Jong-Eun Kim, Sung-Young Lee, Jun Seong Park, Myung Hun Yeom, Hanyong Chen, Ann Bode, Zigang Dong, Ki Won Lee (2014). The daidzein metabolite 6,7,4’-trihydroxyisoflavone is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1. International Journal of Molecular Sciences 15(11):21419-32

21.   Tae-Gyu Lim, Sung-Young Lee, Do Young Lim, Zunnan Huang, Sung Keun Jung, Ann M. Bode, Ki Won Lee, and Zigang Dong (2014). Curcumin suppresses proliferation of colon cancer cells by targeting CDK2. Cancer Prevention Research 7(4): 466-474

22.   Tae-Gyu Lim, Dong Joo Shin, Jong-Eun Kim, Mun Kyung Hwang, Jeong Ah Hwang, Nam Joo Kang, Gaeun Park, Jun-Seong Park, Myeong-Hun Yeom, Deok Kun Oh, Jiyoung Kim, Ann M. Bode, Zigang Dong, Hyong Joo Lee, Ki Won Lee (2014). 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol suppresses UVB-induced MMP-1 expression through AMPK-mediated mTOR inhibition as a downstream of the PKA-LKB1 pathway. Journal of Cellular Biochemistry 115(10):1702-11

23.   Tae-Gyu Lim, Sung-Young Lee, Hanyong Chen, Sung Keun Jung, Hyo-Jeong Lee, Mee-Hyun Lee, Dong Joon Kim, Aram Shin, Ki Won Lee, Ann M. Bode, Young-Joon Surh and Zigang Dong (2013). Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin. Cancer Prevention Research 6(12):1356-64

24.   Tae-Gyu Lim, Sung Keun Jung, Jong-Eun Kim, Yan Li, Ann M. Bode, Jun-Seong Park, Myeong Hun Yeom, Zigang Dong, and Ki Won Lee (2013). MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes. Biochemical Pharmacology (86): 896-903

25.   Tae-Gyu Lim, Min-Yu Chung, and Ki Won Lee (2013). Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development. World Journal of Gastroenterology. 19(7): 984-993

26.   Tae-Gyu Lim, Sung Keun Jung, Jong-Eun Kim, Yoona Kim, Hyong Joo Lee, Tae Su Jang and Ki Won Lee (2013). NADPH oxidase is a novel target of delphinidin to inhibits UVB-induced MMP-1 expression in human dermal fibroblasts. Experimental Dermatology 22(6): 428-430

27.   Tae-Gyu Lim, Ji Hye Yoon, Kyung Mi Lee, Ae Ji Jeon, Su Yeon Kim, and Ki Won Lee (2011). Tangeretin Reduces Ultraviolet B (UVB)-Induced Cyclooxygenase-2 Expression in Mouse Epidermal Cells by Blocking Mitogen-Activated Protein Kinase (MAPK) Activation and Reactive Oxygen Species (ROS) Generation. Journal of Agricultural and food chemistry 59(1): 222-228

28.   Tae-Gyu Lim, Bo Kyung Lee, Jung Yeon Kwon, Sung Keun Jung, and Ki Won Lee (2011). Acrylamide up-regulates clcyooxygenase-2 expression through the MEK/ERK signaling pathway in mouse epidermal cells. Food and Chemical Toxicology 49(6): 1249-1254

29.   Tae-Gyu Lim, Jung Yeon Kwon, Jiyoung Kim, Nu Ry Song, Kyung Mi Lee, Yong-Seok Heo, Hyong Joo Lee, and Ki Won Lee (2011). Cyanidin-3-glucoside suppresses B[a]PDE-induced cyclooxygenase-2 expression by directly inhibiting Fyn kinase activity. Biochemical Pharmacology 82(2): 467-174

30.   Ahmad Rois Mansur, Nho-Eul Song, Hae Won Jang, Tae-Gyu Lim, Miyoung Yoo, Tae Gyu Nam (2019). Optimizing the ultrasound-assisted deep eutectic solvent extraction of flavonoids in common buckwheat sprouts. Food Chemistry 30;293:438-445

31.   Nho-Eul Song, Dan-Bi Kim, Tae-Gyu Lim, Yun-Yeol Lee, Miyoung Yoo, Tae Gyu Nam (2019). Determining pesticide residues in wheat flour by ultrahigh-performance liquid chromatography/quadrupole time-of-flight mass spectrometry with QuEChERS extraction. Food Additives & Contaminants 28:1-11

32.   Young-Ran Song, Ah-Ram Han, Tae-Gyu Lim, Eun-Jung Lee, Hee-Do Hong (2019). Isolation, purification, and characterization of novel polysaccharides from lotus (Nelumbo nucifera) leaves and their immunostimulatory effects. International Journal of Biological Macromolecules 128:546-555

33.   Young-Ran Song, Ah-Ram Han, Tae-Gyu Lim, Ji-Hyun Kang, Hee-Do Hong (2019) Discrimination of Structural and Immunological Features of Polysaccharides from Persimmon Leaves at Different Maturity Stages. Molecules 24(2)

34.   Ahmad Rois Mansur, Hyun Jun Lee, Hyo‐Kyoung Choi, Tae‐Gyu Lim, Miyoung Yoo, Hae Won Jang, Tae Gyu Nam (2018) Comparison of two commercial solid‐phase microextraction fibers for the headspace analysis of volatile compounds in different pork and beef cuts. Journal of Food Processing and Preservation 42(10)

35.   Ah-Ram Han, Tae-Gyu Lim, Young-Ran Song, Mi Jang, Young Kyoung Rhee, Hee-Do Hong, Mi-Hyun Kim, Hyun-Jin Kim, Chang-Won Cho (2018) Inhibitory Effect of Opuntia humifusa Fruit Water Extract on Solar Ultraviolet-Induced MMP-1 Expression International Journal of Molecular Sciences 19(9)

36.   Young-Ran Song, Su-Kyung Sung, Mi Jang, Tae-Gyu Lim, Chang-Won Cho, Chun-Ji Han, Hee-Do Hong (2018) Enzyme-assisted extraction, chemical characteristics, and immunostimulatory activity of polysaccharides from Korean ginseng (Panax ginseng Meyer) International Journal of Biological Macromolecules 116:1089-1097

37.   Seung Joon Lee, Ji Su Lee, Eunjung Lee, Tae-Gyu Lim, Sanguine Byun (2018). The ginsenoside metabolite compound K inhibits hormone-independent breast cancer through downregulation of cyclin D1. Journal of Functional Foods 46:159-166

38.   Hyein Jeon, Jae Hwan Kim, Eunjung Lee, Young Jin Jang, Joe Eun Son, Jung Yeon Kwon, Tae-Gyu Lim, Sunghoon Kim, Jung Han Yoon Park, Jong-Eun Kim, Ki Won Lee (2016). Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo. Oncotarget 7(41): 67223-67234

39.   Jong-Eun Kim, Eunmiri Roh, Mee Hyun Lee, Dong Hoon Yu, Dong Joon Kim, Tae-Gyu Lim, Sung Keun Jung, Cong Peng, Yong-Yeon Cho, Sally Dickinson, Dave Alberts, G. Tim Bowden, Janine Einspahr, Steven P Stratton, Clara Curiel, Ann M. Bode, Ki Won Lee, Zigang Dong (2016). Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis. Oncogene 35(31) 4091-4101

40.   Ji Hoon Lee, Jong-Eun Kim, Young Jin Jang, Charles C. Lee, Tae-Gyu Lim, Sung Keun Jung, Eunjung Lee, Soon Sung Lim, Yong Seok Heo, Sang Gwon Seo, Joe Eun Son, Jong Rhan Kim, Chang Yong Lee, Hyong Joo Lee, Ki Won Lee (2015). Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. Molecular Carcinogenesis 55(5):552-62

41.   Gaeun Park, Sohee Baek, Jong-Eun Kim, Tae-Gyu Lim, Charles C. Lee, Hee Yang, Young-Gyu Kang, Jun Seong Park, Martin Augustin, Michael Mrosek, Chang Yong Lee, Zigang Dong, Robert Huber, Ki Won Lee (2015). Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging. Biochemical Pharmacology 98(3):473-83

42.   Won Bum Huh, Jong-Eun Kim, Young-Gyu Kang, Gaeun Park, Tae-Gyu Lim, Jung Yeon Kwon, Da Som Song, Eun Hee Jeong, Charles C. Lee, Joe Eun Son, Sang Gwon Seo, Eunjung Lee, Jong Rhan Kim, Ki Won Lee (2015). Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K. Plos One 10(6):e0128365

43.   Sein Lee, Jong-Eun Kim, Sujin Suk, Oh Wook Kwon, Gaeun Park, Tae-Gyu Lim, Sang Gwon Seo, Jong Rhan Kim, Dae Eung Kim, Miyeong Lee, Dae Kyun Chung, Jong Eun Jeon, Dong Woon Cho, Byung Serk Hurh, Sun Yeou Kim, Ki Won Lee (2015). A fermented barley and soybean formula enhances skin hydration. Journal of Clinical Biochemistry and Nutrition 57(2):156-6

44.   Jong-Eun Kim, Joe Eun Son, Hyein Jeong, Dong Joon Kim, Sang Gwon Seo, Eunjung Lee, Tae-Gyu Lim, Jong Rhan Kim,Yengo Raymond Kimbung, Hanyong Chen, Ann M. Bode, Ki Won Lee, Zigang Dong (2015). A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer. Cancer Research 75(13): 2716-2728

45.   Sung Keun Jung, Mee-Hyun Lee, Do Young Lim, Sung Young Lee, Chul-Ho Jeong, Jong Eun Kim, Tae-Gyu Lim, Hanyong Chen, Ann M. Bode, Hyong Joo Lee, Ki Won Lee, Zigang Dong (2015).  Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth. Molecular Carcinogenesis 54(4):322-331

46.   Sung Keun Jung, Su Jeong Ha, Yeong A Kim, Jihoon Lee, Tae-Gyu Lim, Yun Tai Kim, Nam Hyouck Lee, Jun Seong Park, Myeong-Hun Yeom, Hyong Joo Lee, Ki Won Lee (2015) MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo. Journal of Cellular and Molecular Medicine 19(1): 135-142

47.   Sung Keun Jung, Mee-Hyun Lee, Do Young Lim, Jong Eun Kim, Puja Singh, Sung-Young Lee, Chul-Ho Jeong, Tae-Gyu Lim, Hanyong Chen, Young-In Chi, Joydeb Kumar Kundu, Nam Hyouck Lee, Charles C. Lee, Yong-Yeon Cho, Ann M. Bode, Ki Won Lee, Zigang Dong (2014) Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wildtype and L858R/T790M Mutant EGFR. Journal of Biological Chemistry 289(52): 35839-35848

48.   Seunghwan Choi, Tae-Gyu Lim, Mun Kyung Hwang, Jiyoung Kim,Yoon-A Kim, Ki Won Lee (2013). Rutin inhibits B[a]PDE-induced cyclooxygenase-2 expression by targeting EGFR kinase activity. Biochemical Pharmacology 86(10):1468-75

49.   Yun Sun Lee, Hyun Kyoung Ju, Yeon Jeong Kim, Tae-Gyu Lim, Md Romij Uddin, Yeon Bok Kim, Jin Hong Baek, Sung Won Kwon, Ki Won Lee, Hak Soo Seo, Sang Un Park, Tae-Jin Yang (2013). Enhancement of anti-inflammatory activity of Aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation. Plos One 8(12):e82479

50.   Sung Keun Jung, Tae-Gyu Lim, Sang Gwon Seo, Hyong Joo Lee, Young-Sun Hwang, Myoung-Gun Choung, Ki Won Lee (2013). Cyanidin-3-O-(2"-xylosyl)-glucoside, an Anthocyanin from Siberian ginseng (Acanthopanax senticosus) Fruits, Inhibits UVB-induced COX-2 Expression and AP-1 Transactivation. Food Science and Biotechnology 22(2). 507-513

51.   Done Eun Lee, Min-Yu Chung, Tae-Gyu Lim, Hyong Joo Lee, and Ki Won Lee (2013). Quercetin Suppresses Intracellular ROS Formation, MMP Activation, and Cell Motility in Human Fibrosarcoma Cells. Journal of Food Science 79(8). H1464-H1469

52.   Sung Keun Jung, Jong Eun Kim, Sung-Young Lee, Mee Hyun Lee, Sanguine Byun, Young A Kim, Tae-Gyu Lim, Kanamata Reddy, Zunnan Huang, Ann M. Bode, Hyong Joo Lee, Ki Won Lee, Zigang Dong (2013). The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer. Carcinogenesis 35(1):123-30

53.   Dong Eun Lee, Ki Won Lee, Sung Keun Jung, Eun Jung Lee, Jung A. Hwang, Tae-Gyu Lim, Bo Yeon Kim, Ann M. Bode, Hyong Joo Lee, and Zigang Dong (2011). 6,7,4′-Trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2.  Carcinogenesis 32(4). 629-635

54.   Ae Ji Jeon, Tae-Gyu Lim, Sung Keun Jung, Eun Jung Lee, Myeong Hun Yeom, Jun Seong Park, Myoung-Gun Choung, Hyong Joo Lee, Yoongho Lim, and Ki Won Lee (2011). Black Soybean (Glycine max cv. Heugmi) Seed Coat Extract Suppresses TPA or UVB-induced COX-2 Expression by Blocking Mitogen Activated Protein Kinases Pathway in Mouse Skin Epithelial Cells. Food Science and Biotechnology 20(6): 1735-1741

55.   Sung Keun Jung, Tae-Gyu Lim, Jong Eun Kim, Sanguine Byun, Gye Won Kim, Jung, Nam Choi, Choong Hwan Lee, Bo Yeon Kim, Ki Won Lee, and Hyong Joo Lee (2011). Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acarithopanax sessiliflorus. Food Chemistry 130(4): 915-920.

56.   장미, 임태규, 홍희도, 이영경, 김경탁, 이은정, 이정훈, 이윤지, 김연복, 조장원 (2016). 한외거르기 (Ultrafiltration)에 의하여 분리된 백수오 고분자 분획물의 면역증진 활성. 한국식품과학회지 48(3): 268-274

57.   김은영, 김염, 김경탁, 임태규, 장미, 조장원, 이영경, 홍희도 (2016). 고온고압 처리가 홍삼의 이화학적 특성 및 항산화 효과에 미치는 영향. 한국식품영양학회지 29(3): 438-447

58.   김희정, 김미현, 장미, 임태규, 홍희도, 이영경, 김경탁, 조장원 (2016). 천년초 줄기의 수확 시기 별 외관 및 성분 품질 특성. 한국식품저장유통학회지 23(4): 502-509

59.   김미현, 김희정, 장미, 임태규, 홍희도, 이영경, 김경탁, 조장원 (2016). 손바닥선인장 (백년초, 천년초) 열매의 외관 및 성분특성 연구. 한국식품저장유통학회지 23(5): 711-717

60.   김염, 김경탁, 임태규, 장미, 조장원, 이영경, 홍희도 (2016). 원료삼 크기와 형태가 흑삼의 품질에 미치는 영향. 한국식품영양학회지 29(5):610-617

61.   Chang-Won Cho, Sungeun Ahn, Tae-Gyu Lim, Hee-Do Hong, Young Kyoung Rhee, Deok-Chun Yang, Mi Jang (2017). Cynanchum wilfordii Polysaccharides Suppress Dextran Sulfate Sodium-Induced Acute Colitis in Mice and the Production of Inflammatory Mediators from Macrophages. Mediators of Inflammation 2017;2017:3859856

62.   Mi Jang, Young-Chul Lee, Hee-Do Hong, Young Kyoung Rhee, Tae-Gyu Lim, Kyung-Tack Kim, Feng Chen, Hyun-Jin Kim, Chang-Won Cho (2017). Anti-oxidative and anti-inflammatory activities of devil’s club (Oplopanax horridus) leaves. Food Science and Biotechnology 26(1):213-220

63.   Hee-Do Hong, Jong-Chan Kim, Tae-Gyu Lim, Young-Ran Song, Chang-Won Cho, Mi Jang (2018). Mixing ratio optimization for functional complex extracts of Rhodiola crenulata, Panax quinquefolius, and Astragalus membranaceus using mixture design and verification of immune functional efficacy in animal models. Journal of Functional Foods 40:447-454

64.  Ke Yao, Sung-Young Lee, Cong Peng, Do Young Lim, Hiroyuki Yamamoto, Joohyun Ryu, Tae-Gyu Lim, Hanyong Chen, Guoguo Jin, Zhenjiang Zhao, Yaping Han, Wei-Ya Ma, Ann M. Bode, Zigang Dong (2018). RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation. Oncogene 37(26):3501-3513

65. Song, Young-Ran, Lim, Won-Chul, Han, Ahram, Lee, Myung-Hee, Shin, Eun Ju, ,Lee, Kwang-Min, Nam, Tae-Gyu, Lim, Tae-Gyu (2020). Rose Petal Extract (Rosa gallica) Exerts Skin Whitening and Anti-Skin Wrinkle Effects

66. Lim, Won-Chu, Choi, Hyo-Kyung, Kim, Kyung-Tack, Lim, Tae-Gyu (2020). Rose (Rosa gallica) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway