연구활동 Research activities

논문
  • [국외]
  • Senescent astrocytes derived from human pluripotent stem cells reveal age-related changes and implications for neurodegeneration, Aging and Disease (2025)
  • Autoinhibited Protein Database: a curated database of autoinhibitory domains and their autoinhibition mechanisms, Database : the journal of biological databases and curation 2024 (2024)
  • Corydalis ternata Nakai Alleviates Cognitive Decline in Alzheimer's Disease by Reducing β-Amyloid and Neuroinflammation, Rejuvenation Research 27 (2024)
  • Preventive effect of peptides derived from fermented milk on chronic stress-induced brain damage and intestinal dysfunction in mice, Journal of Dairy Science 106 (2023)
  • A multi‐layered network model identifies Akt1 as a common modulator of neurodegeneration, Molecular Systems Biology 19 (2023)
  • Differentiation of astrocytes with characteristics of ventral midbrain from human embryonic stem cells, Stem Cell Reviews and Reports 19 (2023)
  • 14-3-3γ haploinsufficiency leads to altered dopamine pathway and Parkinson’s disease-like motor incoordination in mice, Molecular Brain 16 (2023)
  • Conditional deletion of TMEM16A in cholinergic neurons of the medial habenula induces anhedonic-like behavior in mice, Behavioural Brain Research 426 (2022)
  • Analysis methods for the gut microbiome in neuropsychiatric and neurodegenerative disorders, Computational and Structural Biotechnology Journal 20 (2022)
  • Trophoblast glycoprotein: a new candidate gene for Parkinson’s disease, npj Parkinsons Disease 7 (2021)
  • Protective Effects of Milk Casein on the Brain Function and Behavior in a Mouse Model of Chronic Stress, Journal of Agricultural and Food Chemistry 69 (2021)
  • Glycated milk protein fermented withLactobacillus rhamnosusameliorates the cognitive health of mice under mild-stress condition, Gut Microbes 11 (2020)
  • Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons, Scientific Reports 7 (2017)
  • Analysis of the Lipid Profiles in Sectional Bovine Brain via Non-Catalytic Rapid Methylation, Analyst 140 (2015)
  • Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo, Neurobiology Of Aging 36 (2015)
  • JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death, TOXICOLOGY 328 (2015)

  •  
  • [국내]
  • Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit, Food Science and Biotechnology (2024)
  • Protective effects of Lacticaseibacillus rhamnosus IDCC3201 on motor functions and anxiety levels in a chronic stress mouse model, FOOD SCIENCE OF ANIMAL RESOURCES 43 (2023)
  • 14-3-3 gamma Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors, Experimental Neurobiology 28 (2019)
특허
  • [국외]
  • 신규 퇴행성 신경질환 치료용 약학적 조성물, 2023-05 (출원)
  • 신규 퇴행성 신경질환 치료용 약학적 조성물, 2021-11 (출원)

  •  
  • [국내]
  • 현호색을 유효성분으로 포함하는 알츠하이머병 예방 또는 치료용 조성물, 2024-01 (출원)
  • 신규 퇴행성 신경질환 치료용 약학적 조성물, 2021-11 (출원)
  • 신규 퇴행성 신경질환 치료용 약학적 조성물, 2020-11 (출원)
  • 주의력 결핍/과잉행동장애 진단용 마커로서의 14-3-3γ의 용도, 2020-09 (등록)
학술발표
  • Behavioral Analysis of TWIK1 Knockout in Alzheimer's Disease Model Mice, The 27th annual meeting of the Korean Society for Brain and Neural Sciences in conjunction with the 18th biennial meeting of the Asian-Pacific Society for Neurochemistry(KSBNS-APSN), 2024-10
  • TMEM16B Dysfunction Induced Impaired Motor Coordination and Hyperactive Behavior in Mice., The 26th Annual Meeting of the Korean Society for Brain and Neural Sciences(the Korean Society for Brain and Neural Sciences), 2023-09
  • Effects of a probiotic Lactobacillus strain on behavioral response and feces metabolite content during chronic mild stress in mice , 한국실험동물학회 동계심포지엄(한국실험동물학회 ), 2023-02
  • 14-3-3γ dysfunction leads to changes in neurotransmitter metabolism and abnormal behaviors like Parkinson’s disease in mice, International Conference KSMCB 2021(The Korean Society for Molecular and Cellular BIology), 2021-11
  • 5XFAD Mice on a C57BL/6J Background Exhibit More Severe Degenerations in Behavioral Phenotypes in Female or Aged Group, International Conference KSMCB 2021(The Korean Society for Molecular and Cellular BIology), 2021-11
  • TMEM16A deficiency of cholinergic neurons in medial habenula induces anhedonia-like behaviors, International Conference KSMCB 2021(The Korean Society for Molecular and Cellular BIology), 2021-11
  • Effect of Probiotics on Cognitive Function in a Mouse Model , KMB 2021 48th Annual Meeting and International Symposium(The Korean Society for Microbiology and Biotechnology), 2021-06
  • Evaluation of Cognitive Function of Dairy Foods in A Mouse Model under Mild Stress Condition, 53rdKoSFA International Symposium and Annual Meeting(Korean Society for Food Science of Animal resources), 2021-05
  • Nherf1 Haplodeficiency causes on anxiety-like behavior in mice, The 23rd Annual meeting of the Korean Society for Brain and Neural Sciences(The Korean Society for Brain and Neural Sciences), 2020-11
  • Conditional knockout of the TMEM16A in cholinergic neurons induces anhedonia-like behaviors , The 23rd Annual meeting of the Korean Society for Brain and Neural Sciences(The Korean Society for Brain and Neural Sciences), 2020-11
  • 14-3-3γ haplodeficiency leads to anxiety-like behavior and defect of motor coordination in mice, The 23rd Annual meeting of the Korean Society for Brain and Neural Sciences(The Korean Society for Brain and Neural Sciences), 2020-11
  • 14-3-3gamma haploinsufficient mice display hyperactive and stress-sensitive behaviors, Neuroscience 2019(Society for Neuroscience), 2019-10
  • Basal Hyperactivity and Sensitive Behavior in Response to Acute Stress in ywhag +/- mice, 제21회 한국뇌신경과학회 정기국제학술대회(The Korean Society for Brain and Neural Sciences), 2018-08
  • Effects of Nherf1 deficiency on mood-related behaviors in mice, 제21회 한국뇌신경과학회 정기국제학술대회(The Korean Society for Brain and Neural Sciences), 2018-08
  • Genetic Reduction of Mitochondrial Complex I Activity Promotes Parkinson's Disease Non-motor Symptoms, the Korean Genetics Society symposium(한국 유전학회), 2017-08
  • Midbrain specific genetic deletion of calcium activated chloride channel induces behavioral changes in mice, The 20th Annual Meeting ofthe Korean Society for Brain and Neural Science(he Korean Society for Brain and Neural Science), 2017-08
  • Altered behaviors in cholinergic neurons specific Calcium-activated chloride channels (CaCC) KO mouse, International Conference of the Korean Society for Molecular and Cellular Biology( 한국분자·세포생물학회), 2016-10
  • Primary neuron culture from mesencephalon of mouse single embryo, International Conference of the Korean Society for Molecular and Cellular Biology( 한국분자·세포생물학회), 2016-10
  • Behavioral changes in cholinergic neurons specific calcium-activated chloride channels (CaCC) KO mouse, Intelligent Brain 2016(한국뇌신경과학회), 2016-09
  • Genetic reduction of mitochondrial complex I activity leads to impairment of learning and memory, International Conference of the Korean Society for Molecular and Cellular Biology(the Korean Society for Molecular and Cellular Biol), 2015-09
  • Loss of mitochondrial complex I activity does not affect pestcide-induced dopaminergic neuron death, EMBO/EMBL Symposium Mechanisms of Neurodegeneration(The EMBO Journal), 2015-06
  • Role of JNK in rotenone-induced dopaminergic neuron death, Brain conference 2014(The Korean society of Brain and Neural Science), 2014-11
  • Reduced mitochondrial complex I function in dopaminergic neurons promotes Parkinsonism without loss of dopamine neurons, International Conference of the Korean Society for Molecular and Cellular Biology(Korean Society for Molecular and Cellular Biology), 2014-10
  • INVESTIGATION OF DOPAMINE SYSTEM USING KNOCK-OUT MICE WITH SPECIFIC LOSS OF DOPAMINERGIC NEURON ACTIVITY, Decoding neural circuit structure and function(European Molecular Biology Organization (EMBO)), 2014-09