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10월 2일 목요일 세종대-건국대 대학원세미나 초청강연 수업이 진행될 예정입니다.

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연사: 이화여자대학교,  장원준 교수님

일자: 10월 2일 목요일 오후5시부터~

장소: 건국대학교 과학관201호

Nickel-Catalyzed Cross-Electrophile Coupling for Enantioselective C(sp³)–C(sp²) and C(sp³)–C(sp) Bond Formation

초록:

Nickel-catalyzed cross-electrophile coupling (XEC) has emerged as a powerful and versatile strategy for C–C bond formation, allowing the use of readily available electrophiles while avoiding the need for pre-functionalized organometallic nucleophiles. In this presentation, our recent developments in Ni-catalyzed XEC will be discussed, focusing on two key transformations: (1)  the alkylation of alkynyl halides1 and (2) the enantioselective alkylation of aryl halides using unactivated alkyl halides.2 Mechanistic studies have revealed that the alkylation of alkynyl halides proceeds via an unexpected pathway, distinct  from previously  reported  XEC  mechanisms,  providing new  insights  into  Ni- catalyzed  XEC reactions. For the alkylation of aryl halides, a  chiral nickel catalyst system was employed  to  achieve  enantioselective  cross-electrophile  coupling. Furthermore,  a  unique  chain- walking strategy was developed to enable divergent functionalization directly from alkyl halides, expanding the synthetic utility of XEC.